Abstract
Abstract The role of the cortex at the medial aspect of the frontal lobe for the subjective control of behaviour has been elaborated in recent years. As apparent from meta-analyses of functional imaging studies, the medial frontal cortex accommodates critical nodes in a caudo-rostral gradient that are involved in the evaluation of sensorimotor, empathic and abstract information. Brain electrical activity was found to be changed in the medial frontal cortex as early as 120 ms after stimulus presentation in relation to the modulation of perception. These functions become established during adolescence, mediating subjective perspective in a social context. They are most likely brought about by dedicated neurons of the mirror neuron system, but subcortical connections suggest a relationship to the reward system. While lesions of the medial frontal cortex such as brain infarction and brain tumours are rare, impairments of medial frontal cortex functions occur quite frequently in neurological, psychiatric and psychosomatic disorders. Essentially, the medial frontal cortex is closely connected to the concept of personality, opening up an approach for an interdisciplinary scientific discourse.
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