The Mechanical Interpretation of Ocular Response Analyzer Parameters.

Abstract

Purpose Ocular Response Analyzer (ORA) is one of the most widely used devices in clinic, while the mechanical interpretations of parameters obtained from ORA have not been understood completely. The aim of this research is to explore the mechanical interpretation of ORA parameters. Methods Rabbits aged 3-24 months were measured with ORA in vivo and corneal strips uniaxial tensile tests to get ORA parameters and corneal biomechanical parameters (corneal elastic modulus, relaxation time, and relaxation limit). The mechanical interpretation of ORA parameters was cognized preliminarily by analyzing the correlation between ORA parameters and corneal biomechanical parameters. On the other hand, finite element method was applied to simulate ORA measurements with different corneal biomechanical parameters to obtain quantitative relationship between ORA parameters and corneal biomechanical parameters further. Results Biomechanical experimental results showed that Corneal Resistance Factor (CRF) was correlated with corneal elastic modulus and relaxation limit significantly, while the significant correlations between Corneal Hysteresis (CH) and corneal biomechanical parameters were not observed. Results of finite element analysis showed that both CH and CRF were correlated with corneal elastic modulus, relaxation limit, and relaxation time significantly. Besides, corneal elastic modulus was positively correlated with upslop1 and upslop2 and negatively correlated with w2. Conclusions For all ORA parameters, CH, CRF, the upslope, and the width of the peaks are parameters which may reflect corneal elastic properties. It is viable to cognize mechanical interpretation of ORA parameters by the comparisons of the data from ORA and biomechanical tests of rabbits with different ages and the simulations of ORA based on finite element methods. Further studies are needed to confirm the mechanical interpretation.