THE MEANING OF PEROXIDATION AND ANTIOXIDANT SYSTEMS IN THE PATHOGENESIS OF BRONCHIAL OBSTRUCTION

Abstract

The pathogenesis of several diseases of respiratory system, in particular recurrent obstructive bronchitis and bronchial asthma are founded on syndrome of bronchial obstruction. The study of the pathogenesis aspects of these diseases is essential to improve the efficiency of treatment and rehabilitation of patients. Patients with bronchial obstruction syndrome have imbalance between reactions of lipid peroxidation and antioxidant system with a significant damage to biological membranes at the cellular and subcellular level. Metabolic response in these patients have lower compensatory capacity, that leads to development of more severe forms of the disease. The analysis of the data obtained showed that prior to initiating therapy in children with recurrent obstructive syndrome was a decrease in antioxidant protection indicators (ceruloplasmin content and catalase activity in blood serum) and an increase in indicators of intoxication (malondialdehyde content in the blood serum). After the use of polyoxidonium in a complex therapy the patients showed a reliable increase in the content of ceruloplasmin and catalaza activity in the blood serum and decrease in the content of malondialdehyde in the blood serum. It was found that before treatment patients had an increase in the index of intoxication (nitric oxide), after the use of polyoxidonium in a complex therapy they had a significant reduction of nitric oxide in the blood serum.