[The markers of dysfunction of endothelium and cytokine profile in patients with metabolic syndrome and abdominal obesity.]

Abstract

The publications of Russian and foreign researcher are described the alterations of cellular and humoral chain of immunity under obesity and metabolic syndrome. However, the presented facts are in many ways contradictory. The data concerning the level of markers of dysfunction of endothelium and indices of immune status in patients with isolated abdominal obesity is absent in available literature. At the same time, exactly abdominal obesity is an obligatory criterion of metabolic syndrome and adipokinins synthesized in visceral adipose tissue, induce homeostasis disorders and maintain sub-clinical chronic inflammation concomitant to metabolic syndrome. The article presents the results of study of markers of dysfunction of endothelium and cytokine profile in young patients of both gender with metabolic syndrome and isolated abdominal obesity. It is established that in patients with isolated abdominal obesity the level of markers of dysfunction of endothelium (angiotensin II, endothelin I-21, inhibitor of activator of plasminogen type I, inhibitor of tissue factor path, homocysteine) and cytokine profile (interleukin 1β, 2, 4, 6,8, 10, monocytic chemo-attractive protein type I) have no differences with indices of healthy people. However, content of markers of dysfunction of endothelium is associated with level of pro-inflammatory cytokines (the level of inhibitor of tissue factor path correlates with concentration of interleukin-6, r= -0.964). in patients with metabolic syndrome it was established increasing of concentration of angiotensin II, inhibitor of activator of plasminogen type I, inhibitor of tissue factor path, monocytic chemo-attractive protein type I and interleukin-10. The content of angiotensin II and endothelin I-21 correlates with level of interleukin-6 (r=0.416 and 0.445 correspondingly) and concentration of homocysteine with content of interleukin-8 (r=0.0459).