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Article1 February 1955THE MANAGEMENT OF REFRACTORY EDEMA IN HEART FAILUREALBERT L. RUBIN, HARTWELL G. THOMPSON JR., WARREN S. BRAVEMAN, E. HUGH LUCKEY, F.A.C.P.ALBERT L. RUBINSearch for more papers by this author, HARTWELL G. THOMPSON JR.Search for more papers by this author, WARREN S. BRAVEMANSearch for more papers by this author, E. HUGH LUCKEY, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-2-358 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report is concerned with edema which is refractory to usual methods of treatment. Most patients with heart failure eventually develop edema. Often this is an early manifestation. Many factors contribute to the retention of salts and water which produce an excess of extracellular fluid. In some respects the edema of heart failure may be considered only a symptom, indirectly reflecting the derangement of hemodynamics which characterize this state. From evidence which has been accumulated from many sources, it is now generally accepted that under certain circumstances the expansion of extracellular fluid, per se, may contribute to the failure of...Bibliography1. Batterman RC: The status of mercurial diuretics for the treatment of congestive heart failure, Am. Heart J. 42: 311, 1951. CrossrefMedlineGoogle Scholar2. HanlonGilroyRomaineDeitrickLuckey LWFJMJEEH, to be published. Google Scholar3. SchwartzWallace WBWM: Electrolyte equilibrium during mercurial diuresis, J. Clin. Investigation 30: 1089, 1951. CrossrefMedlineGoogle Scholar4. AxelrodCappsPitts DRJNRF: Potentiation of diuretic action of Salyrgan by ammonium chloride, Federation Proc. 9: 6, 1950. Google Scholar5. FriedbergHalpern CKM: Effect of carbonic anhydrase inhibitor 6063 on renal excretion of fluid and electrolytes in patients with congestive heart failure, Federation Proc. 11: 49, 1952. Google Scholar6. Belsky H: Use of a new oral diuretic, Diamox, in congestive heart failure, New England J. Med. 249: 140, 1953. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Presented as a Morning Lecture at the Thirty-fifth Annual Session of the American College of Physicians, Chicago, Illinois, April 7, 1954.From the Second (Cornell) Medical Division, Bellevue Hospital Center, and The Department of Medicine, Cornell University Medical College.This work was supported in part by grants from the James Foundation of New York, Inc., and the United States Public Health Service. 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