Abstract
Lymphocytes from healthy donors and leukemic cells of patients with acute B-lymphoblastic leukemia (BALL-1) and acute myeloid leukemia were exposed to nanoparticles bearing magnetic (Zn-67) and nonmagnetic (total isotope pool) nuclei of zinc. The values of the corresponding magnetic isotope effects determined as the ratio of LD50 magnitudes of preparations with magnetic and nonmagnetic zinc isotopes were 0, 3.5, and 1.5. Morphological studies using confocal and fluorescence microscopy showed apoptotic death of cells with the preparations; as well, there was an increase in the cell aggregation and better aggregation of nanoparticles in the case of 67Zn-NP, which resulted in a decrease of cytotoxicity. However the magnetic isotope effect was observed even in the case of aggregation.
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