Abstract
Lutein (L) and zeaxanthin (Z) status can be quantified by measuring their concentrations both in serum and, non-invasively, in retinal tissue. This has resulted in a unique ability to assess their role in a number of tissues ranging from cardiovascular to central nervous system tissue. Recent reports using animal models have suggested yet another role, a developmental increase in bone mass. To test this, we assessed L and Z status in 63 young healthy adults. LZ status was determined by measuring LZ in serum (using HPLC) and retina tissue (measuring macular pigment optical density, MPOD, using customized heterochromatic flicker photometry). Bone density was measured using dual-energy X-ray absorptiometry (DXA). Although serum LZ was generally not related to bone mass, MPOD was significantly related to bone density in the proximal femur and lumbar spine. In general, our results are consistent with carotenoids, specifically LZ, playing a role in optimal bone health.
Highlights
In a recent experimental study using growing mice as a model, Takeda et al (2017) found that the dietary carotenoid, lutein (L), stimulated bone formation by suppressing bone resorption [1]
The higher areal bone mineral density of the lumbar spine was related to a greater dietary intake of L and zeaxanthin (Z) combined (N = 47, r = 0.35, p < 0.05)
Our results indicate that individuals with a higher areal bone mineral density of the proximal femur and lumbar spine tend to have higher MPOD
Summary
In a recent experimental study using growing mice as a model, Takeda et al (2017) found that the dietary carotenoid, lutein (L), stimulated bone formation (increasing the density of, largely, cortical bone) by suppressing bone resorption [1]. A very similar result, using young mice as a model, was reported by Tominari et al (2017) who found that L enhanced bone mineralization by suppressing osteoclastic bone resorption [2]. A direct study of the role of L on the bone health of humans, is limited to two studies. The higher areal bone mineral density (aBMD) of the lumbar spine was related to a greater dietary intake of L and zeaxanthin (Z) combined (N = 47, r = 0.35, p < 0.05).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
