Abstract
A natural outgrowth of the use of antihistamine compounds in the treatment of allergic dermatoses is the local use of Benadryl (Betadimethyl aminoethyl benzhydryl ether hydrochloride). Friedlaender and Feinberg (1) studied ten ragweed sensitive patients with scratch tests. They showed that when a standard amount of Benadryl (50 mgm. per cc) is added to serial dilutions of ragweed extract or histamine, there was a definite decrease in the flare and to a lesser extent in the wheal in all ten cases. This was compared to the same dilutions of ragweed extracts or histamine used as controls (without the addition of Benadryl, 50 mgm. per cc). Their study indicates that the local application of Benadryl has some antihistamine effev,;.
Published Version
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