The link between gut microbiota and atherosclerosis

Abstract

Infections have been linked to development of cardiovascular complaint and atherosclerosis. Cardio vascular conditions like atherosclerosis are the major cause of mortality and morbidity in the ultramodern society. The rupture of atherosclerotic plaque can induce thrombus conformation, which is the main cause of acute cardiovascular events. Lately, numerous studies have demonstrated that there are some connections between microbiota and atherosclerosis. There are three metabolite pathways by which gut microbiota can affect atherosclerosis. Either original or distant- causing inflammation which might lead to atherosclerotic plaque formation and rupture. Second, metabolism of lipids and cholesterol by gut microbiota can affect atheromatous atheromatous plaque conformation. Third, diet and specific factors that are metabolized by gut microbiota can have various effects on atherosclerosis; for illustration, salutary fiber is beneficial, whereas the bacterial metabolite trimethylamine- N- oxide (TMAO) is considered dangerous. We'll conclude by discussing new remedial strategies for targeting gut microbiota to ameliorate atherosclerosis and related cardiovascular issues.