The levels of serum growth hormone and immunoreactive insulin after administration of antipyretic analgetics.

Abstract

Abstract: The effects of indomethacin (100 mg) and phenylbutazone (250 mg) suppositories and acetylsalicylic acid (1000 mg) as well as placebo tablets on serum growth hormone, serum immunoreactive insulin and blood glucose concentrations were studied in young male volunteers after an overnight fast. Peak drug concentration in serum was reached 60, 120, and 180 minutes after indomethacin (2.1 ± 0.3 μg/ml), acetylsalicylic acid (88.0 ± 13.4 μg/ml) and phenylbutazone (30.8 ± 2.2 μg/ml), respectively. Blood glucose rose from 4.2 ± 0.1 mmol/l to 5.0 ± 0.1 mmol/l (P < 0.001) (n = 21) at 120 minutes after indomethacin and the rise was significant throughout the study. No significant changes in blood glucose were seen after the administration of the other drugs. The levels of serum growth hormone were also significantly increased after indomethacin throughout the study, but not after the other drugs. The mean of the peak serum growth hormone concentration of the subjects (11.7 ± 1.2 ng/ml) (n = 19) was significantly higher after indomethacin than after the other drugs, which did not not differ from each other significantly. There were no significant changes in serum immunoreactive insulin levels after the drugs. However, after acetylsalicylic acid the levels tended to increase and the serum immunoreactive insulin remained significantly higher at 30, 60, and 120 minutes after acetylsalicylic acid (18.5 ± 1.6, 19.1 ± 3.4, and 20.2 ± 3.2 μU/ml) (n = 13) than after placebo (11.2 ± 2.2, 10.1 ± 2.0, and 10.6 ± 1.5 μU/ml) (n = 13) (P < 0.05).