Abstract
Newborns with severe congenital malformations need radical surgical correction as soon as possible for ensure the quality of life of the infant in the future. Pathological changes associated with the underlying pathology may be accompanied to severe disturbances of homeostasis in the postoperative period.
 The aim of the study. To assess the level of ionic composition of plasma in infants with congenital malformations during surgical correction and various types of combined anesthesia.
 Investigated problem: To prevent electrolyte peri- and postoperative complications, it is obligatory to perform preoperative preparation and stabilization of laboratory parameters, for a child with congenital malformations and to monitor they throughout the operation.
 The main scientific results: The electrolyte composition in the examined groups of infants did not show significant differences from age norms. The concentration of potassium was the lowest in group III of the examined in comparison with groups I and II at the stage of preparation for surgery (p=0.0041; p=0.0102), induction of anesthesia (p=0.0053; p=0.0054), while children of groups I and II were diagnosed with a tendency to the upper limit of normal serum potassium levels during all observation periods. Elevated sodium levels were diagnosed in group III at all stages of surgical treatment and in group II of infants with congenital malformations at the stage of the most painful and traumatic moment of surgery (159.94±4.89 – II, 139.27±3.043 – III, p=0.1857).
 The area of practical use of the research results: pediatric anesthesiology
 Innovative technological product: laboratory control
 Scope of the innovative technological product: neonatal intensive care unit, surgery
Highlights
IntroductionProblem description Determination of ion concentration in the blood continues to be relevant, despite the development of instrumental and the latest biochemical methods of analysis used in clinical diagnosis, including in newborns [1, 2]
The concentration of potassium in blood plasma was the lowest in group III of the examined infants as compared with groups I and II at the stage of preparation for surgery (p=0.0041; p=0.0102), induction of anesthesia (p=0.0053; p=0.0054), while infants of groups I and II were diagnosed with a tendency to the upper limit of normal serum potassium levels during all observation periods (Table 3)
The relative decrease in serum potassium in children of group III may indicate its transmineralization to body cells on the background of alkalosis may lead to the formation of hemodynamic and cardiovascular disorders in children and/or the synergism of two anesthetic drugs – sodium oxybutyrate and fentonyl, which potentiates the implementation of side effects in the form of hypokalemia
Summary
Problem description Determination of ion concentration in the blood continues to be relevant, despite the development of instrumental and the latest biochemical methods of analysis used in clinical diagnosis, including in newborns [1, 2]. The determination of concentrations of ions, such as sodium, potassium and calcium ions may be even more important to assess the severity of the condition of sick premature infants, in particular with respiratory and gastrointestinal disorders [1, 2]. In scientific works the values of concentrations of sodium, potassium and calcium ions in the blood of healthy premature infants and newborns with perinatal pathology, etc. Data on the ionic composition of blood in infants during surgery are insufficient
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