Abstract
Progress in genomics has enabled mapping where in the genome Transcription Factors (TFs) bind, yet what TFs do once bound remains poorly understood. One reason is that the transcription activation domains of TFs are constituted of poorly conserved intrinsically disordered domains, limiting the use of classic biochemistry approaches or the identification of conserved motifs. Single-molecule studies of transcription dynamics in living cells are capable of providing unique functional insights into TF activity, but are often limited in throughput.
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