Abstract
BackgroundPancreatic ductal adenocarcinoma (PDAC) is the most aggressive form of pancreatic cancer. Its 5-year survival rate is only 3–5%. Perineural invasion (PNI) is a process of cancer cells invading the surrounding nerves and perineural spaces. It is considered to be associated with the poor prognosis of PDAC. About 90% of pancreatic cancer patients have PNI. The high incidence of PNI in pancreatic cancer limits radical resection and promotes local recurrence, which negatively affects life quality and survival time of the patients with pancreatic cancer.ObjectivesTo investigate the mechanism of PNI in pancreatic cancer, we analyzed the gene expression profiles of tumors and adjacent tissues from 50 PDAC patients which included 28 patients with perineural invasion and 22 patients without perineural invasion.MethodUsing Monte-Carlo feature selection and Incremental Feature Selection (IFS) method, we identified 26 key features within which 15 features were from tumor tissues and 11 features were from adjacent tissues.ResultsOur results suggested that not only the tumor tissue, but also the adjacent tissue, was informative for perineural invasion prediction. The SVM classifier based on these 26 key features can predict perineural invasion accurately, with a high accuracy of 0.94 evaluated with leave-one-out cross validation (LOOCV).ConclusionThe in-depth biological analysis of key feature genes, such as TNFRSF14, XPO1, and ATF3, shed light on the understanding of perineural invasion in pancreatic ductal adenocarcinoma.
Highlights
Pancreatic cancer is a type of common malignant tumor of the digestive tract, the most aggressive form of which is pancreatic ductal adenocarcinoma (PDAC), which has a 5-year survival rate of only 3–5% (Huang et al, 2014)
The gene expression profiles in the tumor and adjacent tissues can represent the difference between pancreatic ductal adenocarcinoma patients with perineural invasion and without perineural invasion
The gene expression in the tumor directly shows the activity of pancreatic ductal adenocarcinoma while the gene expression in the adjacent tissue reflect the microenvironment of the tumor
Summary
Pancreatic cancer is a type of common malignant tumor of the digestive tract, the most aggressive form of which is pancreatic ductal adenocarcinoma (PDAC), which has a 5-year survival rate of only 3–5% (Huang et al, 2014). The poor prognosis of PDAC is largely due to the lack of early symptoms, explosive outcomes, and resistance to treatment (Pour et al, 2003).Currently, there is no effective method to detect pancreatic cancer in its early stages. Pancreatic cancer has poor responses to conventional therapies, such as chemotherapy and irradiation (Rossi et al, 2014). The high incidence of PNI in pancreatic cancer limits radical resection and promotes local recurrence, which negatively affects life quality and survival time of the patients with pancreatic cancer
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