Abstract
The choice of exipients for sublingual tablets “Corvalol” by the method of direct compression was based on the study of the physical properties of the tablet formulations. Three models of tablet formulations were analyzed. It is found that the optimal exipients are β-cyclodextrin, lactose monohydrate 80, potassium acesulfame, magnesium stearate. It has been demonstrated that the conclusions reached through analysis of physical parameters of the tablet formulations are confirmed by actual results of pressing.
Highlights
Sublingual tablets are convenient for the elderly and patients with swallowing problems
Samples preparation: Complexes of β-cyclodextrin with ethyl ester of α-bromo-isovaleric acid and β-cyclodextrin with mint oil were prepared according to the procedure described in [8]
Special attention was paid to the choice of fast dissolving components in the aqueous medium, the use of which would make it possible to obtain a tablet formulation that is suitable for obtaining tablets by direct compression
Summary
Sublingual tablets are convenient for the elderly and patients with swallowing problems. In the modern world solid dosage forms have become increasingly popular by displacing liquid forms This makes development of a drug in tablets similar to “Corvalol” drops promising. One of them is the direct compression method, which requires introduction of an effective disintegrator in the tablet formulation or the use of fast dissolving components. The method does not require the use of water or heating during formulation, and it is optimal for active substances that are unstable in water or thermolabile ingredients This method is very sensitive to the type and proportion of excipients in the tablet composition [7]. The aim of this work was to carry out the experimental studies on choosing excipients and their amounts for obtaining “Corvalol” in the form of sublingual fast dissolving tablets by the method of direct compression
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