Abstract
Why is an understanding of the JAK/STAT signalling pathway important in common skin diseases and how will that knowledge transform therapeutics? From genomes to vaccines, organ transplants to biotechnology, it is fair to say that modern medicine has seen magnificent breakthroughs in the last century. Fundamentally, what has enabled these advancements is an understanding of basic cellular and molecular biology. Among the pivotal discoveries in this field, the Janus kinase/ signal transducer and activator of transcription (JAK/STAT) pathway has emerged as a critical player in some of today’s most debilitating and deadly human diseases, including various cancers, autoimmune disorders, and chronic inflammatory diseases. Now, an understanding of the JAK/STAT pathway has become important in common skin diseases, from predictive biomarkers and disease prognosis to tiny molecules transforming therapeutics.
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