Research Progress of Signal Transducer and Activator of Transcription 3 and Gynecological Malignant Tumour

Abstract

Signal transducer and activator of transcription (STAT) 3 is an important member of signal transducer and activator of transcription(STATs), which was originally identified as a substrate of the Janus kinase(JAK) in Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. It has been demonstrated to receive growth factors and cytokines or other extracellular stimulation. Activated signal transducer and activator of transcription proteins translocate to the nucleus to regulate expression of genes by binding to specific elements within gene promoters, then to regulate tumor-cell proliferation, differentiation and apoptosis. Abnormal activation of the signal transducer and activator of transcription family members have been found in a large group of human malignant tumors.Researches show that abnormal activation of signal transducer and activator of transcription 3 can inhibit apoptosis, thereby promoting tumor-cell proliferation, invasion and metastasis. Instead, by blocking the way, it could inhibit the tumor-cell proliferation and induce apoptosis of cancer cells. Increasing domestic and foreign evidences demonstrate that JAK-STAT pathway may be involved in the oncogenesis of gynecological malignant tumor.With further researches, signal transducer and activator of transcription 3 may provide clues for early diagnosis and prognosis of gynecological malignant tumor, and may provide a new target for therapy, especially for ovarian cancer drug resistance. Key words: signal transducer and activator of transcription (STAT)3; gynecological malignant tumor; Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway; molecular target inhibition