Abstract
1. In a large series of muscle biopsies from cases of pseudohypertrophic muscular dystrophy vitally stained preparations almost invariably showed changes in the terminal motor innervation. 2. The motor end plates showed either pale staining swelling and fusion of the terminal expansions with some simplification of the terminal arborisation or shrinkage and dark staining of the terminal expansions giving the end plate a stumpy appearance. This second change was mainly seen on atrophic muscle fibres. 3. Electron microscopic preparations suggested that the vitality of the neurone was not diminished and the changes seen were secondary to primary disease of the muscle fibre thus providing yet another example of the lability of the structure of the motor end plate in response to changes in its environment.
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