The intervention study of epristeride on intraoperative hemorrhage during transurethral resection of prostate

Abstract

Objective To evaluate the effect of preoperative with epristeride on decreasing intraoperative hemorrhage during transurethral resection of prostate (TURP) and study its mechanism to find out a new way of decreasing intraoperative hemorrhage during TURP. Methods A total of 102 patients with benign prostatic hyperplasia ( BPH ) during September 2006 to March 2008 underwent TURP were enlisted into study. The patients were divided into two groups: the experiment group was preoperated with epristeride 5 mg,twice every day,and were operated 2 months later;the control group were operated under TURP directly after a definite diagnosis. The weight of tissue was recorded before the operation and the volume of irrigating fluid,the operation time and the weight of removed tissue were calculated after the operation to measure the hemoglobin density and calculated the bleeding quantity,bleeding strength and the bleeding index. Results The bleeding quantity was (157.73 ± 68.30) ml,the operation time was (43.71± 6.47) min,bleeding index was (6.25 ±4.18) ml/g and bleeding strength was (2.96 ±1.17) ml/min in the experiment group,while those in the control group were (214.39 ±76.62) ml,(51.15±7.87) min,(7.82 ±4.29) ml/g,(4.30±1.38) ml/min,respectively,there were statistical significance between the two groups (P＜0.01 or ＜0.05). The weight of removed tissue was (26.37 ± 8.23 ) g in the experiment group and (29.65 ±7.21) g in the control group,there was no statistical significance in comparing the removed tissues between the two groups (P ＞0.05). Conclusion Preoperative with epristeride can effectively decrease intraoperarive bleeding during TURP,and then shorten the operation time and reduce the risk of operation. Key words: Pmstatic hyperplasia; Hemorrhage; Transurethral resection of prostate; Epristeride