The Intervening Effect of Preventive Use of Antibacterials During the Perioperative Period in Orthopedic Department

Hui Liu,Qinai Zhu,Suishan Qiu,Lianfang Xue

doi:10.11648/j.ijidt.20210601.16

Abstract

Objective: To assess the effect of orthopedic perioperative antibiotic prophylaxis intervention by clinical pharmacist. Methods: 1467 hospitalized patients in department of orthopedics with perioperative records in eight months in 2019 were chosen. 597 surgical cases before intervention were sampled as the control group, and 870 surgical records were sampled as intervention group. Investigation and analysis were performed in orthopedic perioperative prophylactic antibiotics. Results: Compared with the control group, the intervention group showed increased rationalities and decreased irrationalities in perioperative antibiotic prophylaxis. The unreasonable external use of teicoplanin was significantly decreased, and the postoperative prophylaxis duration was significantly shortened. There were no significant difference in the timing of perioperative antibiotic prophylaxis between two groups. Conclusions: After interventions for the preventive use of antibacterial drugs in orthopedic perioperative period, the rational use of antibacterial drugs has been significantly improved, the irrational use of drugs has been improved, and the effect of drug treatment has been improved. However, there is still a gap between the rational use of antibacterial drugs. Further strengthen supervision and management.

Highlights

The perioperative prophylactic application of antibiotics is mainly to prevent the bacterial infection at the surgical site and reduce the infection rate of postoperative bacteria on the surgical incision, which has an obvious effect on improving the postoperative cure rate [1]
The irrational use of perioperative prophylactic antibiotics leads to the increase of drug-resistant bacteria and the rate of bacterial drug resistance
To better normalize the prophylactic use of antibacterial, the National Health Commission issued the “Guiding Principles for the Clinical Application of Antibacterials” (2015 Edition) [2]. It is stipulated in the principles of perioperative prophylactic application of antibiotics that whether to prophylactic application of antibiotics should be determined by comprehensive factors such as the type of incision corresponding to different operations, the possible types of contaminating bacteria, the duration of the operation and its sensitivity to antibiotics [3, 4]

Summary

Introduction

The perioperative prophylactic application of antibiotics is mainly to prevent the bacterial infection at the surgical site and reduce the infection rate of postoperative bacteria on the surgical incision, which has an obvious effect on improving the postoperative cure rate [1]. To better normalize the prophylactic use of antibacterial, the National Health Commission issued the “Guiding Principles for the Clinical Application of Antibacterials” (2015 Edition) [2]. It is stipulated in the principles of perioperative prophylactic application of antibiotics that whether to prophylactic application of antibiotics should be determined by comprehensive factors such as the type of incision corresponding to different operations, the possible types of contaminating bacteria, the duration of the operation and its sensitivity to antibiotics [3, 4]. If the preventive medication time exceeds 48 hours, Patients are at increased risk of

Methods

Results

Conclusion