A Cross-Section Study of Adverse Drug Event of Antibacterials Drugs for Patients With Preoperative Gynecological and Obstetric Surgery From a Second-Grade Class-A Hospital

Abstract

Objective To study the adverse drug event of antibacterial drugs for patients with preoperative gynecological and obstetrical surgery in a second-grade class-A hospital. Methods A random sampling study was conducted on the use of antibacterial drugs in patients with preoperative gynecological and obstetrical surgery between June 2010 and June 2011. Their clinical data were retrospectively analyzed in the aspects of usage and adverse drug event of antibacterial drugs. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shenyang Women's and Children's Hospital. Informed consent was obtained from all participates. Results Out of 300 patients with preoperative gynecological and obstetrical surgery, 103 (34.33%) had adverse drug event report. The cases that caused by cephalosporins were accounted for the most (53.32%, 201/377), and damage to the digest system (28.12%, 106/377) was the commonest type. Adverse event rate of rational use of antibacterial drugs was significantly lower than that of the irrational use of antibacterial. Conclusions Rational use of antibacterial for gynecologic and obstetric patients with surgical operation could significantly reduce the incidence of adverse drug event in this second-grade class-A hospital in Shenyang. Key words: gynecology and obstetrics; antibacterial; rational use of drug; adverse drug event