Abstract
Alteration in neurogenesis plays a vital role in etiology of brain disease, including mental disorders and neurodegenerative diseases. The brain-derived neurotrophic factor (BDNF) is a key regulator of neural survival, growth and plasticity involved in emotional and cognitive function. It is a well-known neurotropic factor which is involved in neurogenesis process. BDNF is highly vulnerable to stress. Various evidences show a negative impact of the stress hormone glucocorticoids (GCs) on differentiation and survival of neurons, which is also related to the pathophysiology of brain diseases. This review article has demonstrated functional interactions between neurotropic factors and stress hormone in neurogenesis.
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