Abstract
A systematic curation of the literature on Saccharomyces cerevisiae has yielded a comprehensive collection of experimentally observed interactions. This new resource augments current views of the topological structure of yeast's physical and genetic networks, but also reveals that existing studies cover only a fraction of the cell.
Highlights
The advent of high-throughput biology allows us for the first time in history to think concretely about a global representation of the cell
10.2 Journal of Biology 2006, Volume 5, Article 10 Mellor and DeLisi http://jbiol.com/content/5/4/10 used the extensive literature based on decades of research to curate a reference network of known interactions in yeast. This literature-curated collection corresponds to a network of some 33,000 high-confidence interactions between proteins or genes in yeast. It shows little overlap with the published physical [2,3,4,5,6] and genetic [7] interaction networks reported in recent years by large-scale assays
Different views may exist on why this should be, for example in regard to levels and sources of false positives and false negatives in highthroughput datasets [8], but even the most optimistic assessment suggests that tens of thousands of interactions remain to be discovered in yeast
Summary
The advent of high-throughput biology allows us for the first time in history to think concretely about a global representation of the cell. 10.2 Journal of Biology 2006, Volume 5, Article 10 Mellor and DeLisi http://jbiol.com/content/5/4/10 used the extensive literature based on decades of research to curate a reference network of known interactions in yeast.
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