Abstract
Abstract Monovalent antibody fragments produced by the digestion of immune γ-globulin with papain are able to neutralize influenza virus. The complexes formed when influenza virus reacts with the monovalent antibody fragments will dissociate when the reaction mixture is diluted in a medium of neutral pH. This monovalent antibody can protect influenza virus from “irreversible” inactivation by divalent antibody. In the case of vaccinia virus, it has been demonstrated that the neutralizing activity of antibody is correlated with the net charge carried by the antibody molecule. These findings when considered in conjunction with the results of kinetic experiments allow the formulation of a likely physical mechanism to account for the reactions that occur when viruses interact with antibody.
Published Version
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