The Integrated Defense System: Optimizing Defense against Predators, Pathogens, and Poisons.

Abstract

Insects, like other animals, have evolved defense responses to protect against predators, pathogens, and poisons (i.e., toxins). This paper provides evidence that these three defense responses (i.e., fight-or-flight, immune, and detoxification responses) function together as part of an Integrated Defense System (IDS) in insects. The defense responses against predators, pathogens, and poisons are deeply intertwined. They share organs, resources, and signaling molecules. By connecting defense responses into an IDS, animals gain flexibility, and resilience. Resources can be redirected across fight-or-flight, immune, and detoxification defenses to optimize an individual's response to the current challenges facing it. At the same time, the IDS reconfigures defense responses that are losing access to resources, allowing them to maintain as much function as possible despite decreased resource availability. An IDS perspective provides an adaptive explanation for paradoxical phenomena such as stress-induced immunosuppression, and the observation that exposure to a single challenge typically leads to an increase in the expression of genes for all three defense responses. Further exploration of the IDS will require more studies examining how defense responses to a range of stressors are interconnected in a variety of species. Such studies should target pollinators and agricultural pests. These studies will be critical for predicting how insects will respond to multiple stressors, such as simultaneous anthropogenic threats, for example, climate change and pesticides.