Abstract
Our aim was to examine the inhibitory effect of nilvadipine on voltage-gated calcium (Ca) channels in solitary ganglion cells. Eyes were excised from goldfish. Ganglion cells were enzymatically dissociated from isolated retina. Whole-cell currents were recorded with the perforated-patch clamp technique. Depolarizing step pulses to more than -48 mV evoked a slowly inactivating inward Ca current. The current-voltage relation for the nilvadipine-sensitive current was bellshaped, and the peak current reached a maximum at -8 mV in the presence and absence of nilvadipine. Nilvadipine block of voltage-gated Ca current was dose-dependent between 1 and 100 microM. The half-maximum inhibitory dose was 35 microM. The inhibitory effect of orally administered nilvadipine on Ca channels had a mild influence in ganglion cells.
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