Abstract
The purified sample of renastacarcin was tested against various kinds of Gram-positive and -negative bacteria, yeast and fungi. As a result, it was concluded that this compounds was almost devoid of antimicrobial activity even at a concentration of 200 mcg/ml. However, renastacarcin showed a significant antitumor activity both in vitro and in vivo against ascitic type of Ehrlich carcinoma and Sarcoma 180 in mice. When the tumor cells were incubated with renastacarcin, the lysis of cell membrane and subsequent leakage of the cellular contents were observed by means of the optical and microscopical method.The LD50 values of renastacarcin in mice were observed to be 40 mg/kg intraperitoneally, and 23.5 mg/kg intervenously.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
