Abstract
The purpose of the chapter is to shed light on understanding the mechanism of pore formation in the lipid membrane, hemolysis, and factors influencing the pore size. It is crucial to understand the mechanism hemolysis and formation of ion channels in lipid membrane as various progressions such as the antimicrobial activity of peptide; membrane fusion and permeation require the transmembrane pores The various biological applications encompasses important phenomena such as pore formation, solubilization, permeabilization, and lysis of membrane, the biogenic surfactant and detergents are playing a key role in these. These phenomena include the study of interactions of surfactants with membranes of lipids, membrane proteins, leakage and lysis of cell membranes by lipopeptides, antimicrobial activities, thermodynamic and structural facets of membrane–water partitioning, membrane solubilization to micelles and other lipid–surfactant systems, and alterations in properties of membrane brought about by surfactants.
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