Abstract
Abstract In several recent reports, helminthic infections could reduce various allergic response and immune response. In previous study, we demonstrated that Trichinella spiralis infection could ameliorate allergic airway inflammation and CD4+CD25+ Foxp3+ T (Treg) cells were recruited in the lung. In order to know function of recruited T reg cell of T. spiralis infected mice, we elicited allergic airway inflammation with OVA-alum and injected Treg cell by intra-venous which was isolated from T. spiralis infected mice. Treg cells induced with T. spiralis infection inhibit OVA-induced airway inflammation. A significant reduction of immune cell infiltration and the concentrations of IL-4 and IL-13 were lower than those of control. The gene expression levels of various important homing receptors and activated Treg marker in Treg cells of each group were analyzed via real-time PCR. As a result, the expression of CTLA-4, CCR5 and CCR9 was significantly increased in Treg cells by T. spiralis infection. These data identify Treg cells induced by T. spiralis infection as capable of regulating allergic airway responses by migration to inflamed tissues and activation.
Published Version
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