The influences of intraoperative sodium potassium magnesium calcium, glucose injection infusion on hepatic and renal functions, blood electrolytes, glucose, lactate and coagulation function

Abstract

Objective To evaluate influences of intraoperative sodium potassium magnesium calcium and glucose (SPMCG) injection infusion on hepatic and renal functions,blood electrolytes,glucose,lactate and coagulation function.Methods Eighty patients with ASA grade Ⅰ or Ⅱ scheduled for elective general surgery or orthopedic surgery were randomly assigned to experimental group and control group using random number table.Five hundred ml of SPMCG injection (in the experimental group) or sodium lactate ringer injection (in the control group) was infused at the rate of 15 ml·kg-1·h-1 before anesthesia induction,followed by 10 ml·kg-1 ·h-1 for 2 h,and then 8 ml·kg-1 ·h-1 until the end of surgery.Hepatic and renal functions,blood electrolytes and coagulation function were evaluated before and after infusion.Blood glucose and lactate levels were measured before infusion,pre-induction,and 1 h and 2 h after induction,and the end of infusion.Results There were not significantly differences between two groups in the serum levels of alanine aminotransferase,aspartate aminotransferase,albumin,total bilirubin,urea nitrogen and creatinine before and after infusion.The serum concentrations of Na+,K+,Cl-and Ca2+ before and after infusion did not significantly differ between two groups,but the serum concentration of Mg2+ after infusion was higher in the experimental group than in the control group [(0.84± 0.21) mmol/L vs(0.71 ±0.31) mmol/L(P＜0.05)].Blood glucose levels in the two groups increased progressively during surgery,and then decreased to preoperative levels after surgery.There were not significantly differences between two groups in the prothrombin time and activated partial thromboplastin time.Conclusions Intraoperative infusion of SPMCG injection does not result in harmful effects on hepatic and renal functions,blood electrolytes,glucose,lactate and coagulation function.Compared with sodium lactate ringer injection,SPMCG injection can better maintain the serum concentration of Mg2+ during surgery. Key words: Sodium potassium magnesium calcium and glucose injection; Sodium lactate ringer injection; Hepatic and renal function; Electrolytes; Glucose; Lactate; Coagulation function