Correlation between early coagulation function, white blood cells, blood glucose, and the severity and prognosis in patients with traumatic brain injury

Abstract

Objective To explore the correlation between early coagulation function,white blood cells (WBC),blood glucose,and the severity and prognosis in patients with traumatic brain injury (TBI).Methods A total of 126 cases of traumatic brain injury was divided into two groups (mild-moderate injury; and severe injury) based on the Glasgow Coma Scale (GCS).After one month,Oxford handicap scale was employed to assess the prognosis of all the TBI patients,based on that they were divided into the favorable prognosis group and poor prognosis group.Prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB),platelet (PLT),WBC,and blood glucose levels were measured after admission.Thirty cases of health physical examination persons were selected as control group at the same period.The levels of PT,APTT,FIB,PLT,WBC,and blood glucose were compared among different groups.Results The levels of APTT,PT,WBC,and blood glucose in mild-moderate TBI group and severe TBI group were significantly higher than those in the control group,while the levels of PLT and FIB were significantly lower (P ＜ 0.05).The levels of PT,APTT,WBC,and blood glucose were progressively elevated with increasing degree of injury,while the levels of PLT and FIB were decreased (P ＜0.05).Compared to good prognosis group,the levels of PT,APTT,WBC,and blood glucose were gradually increased in poor prognosis group,while PLT,FIB and GCS score were decreased (P ＜0.05).The levels of PT,APTT,WBC,and blood glucose were negatively correlated with GCS score and OHS score,while FIB and PLT were positively correlated (P ＜ 0.05).Conclusions Early coagulation function,WBC,and blood glucose in TBI patients were closely related to brain injury degree and its prognosis,which might be used in evaluation of the severity and prognosis. Key words: Craniocerebral trauma; Blood coagulation ; Leukocytes ; Blood glucose ; Prothrombin time; Prognosis