Abstract
The used of monosodium glutamate (MSG) oftenly found in almost every food that we consumed everyday. It suggested that MSG can increase appetite, can caused intake much foods, and increased the bodyweight. The aim of study is to prove the changes that occur in male mice by induce of MSG. The experimental study used 24 male mice, 30-45 gram, 12-14 weeks divided into 4 groups, ie group-I (negative control/placebo given aquadest 0.2 cc/20gBW mice); group-II, MSG with the dose of 5 mg/gBW mice); group-III, MSG with the dose of 10 mg/gBW mice and group-IV, MSG with the dose of 20 mg/gBW mice. All of these treatments were administered orally for 14 days. Permanent cervical fracture execution was performed at the end of the study. The body weight measured in pre and post treatment. The significant difference of data between different groups was compared by ANOVA followed by Tukey test. The compared of between pre –post treatment used paired test to analyze the changes of bodyweight This study proved that the comparison of mean values ± SEM of body weight between groups were not significantly different; group I (39,83±3,26), group II (39,33±2,04), group III (38,00±1,39) and group IV (38,33±1,76) (p = 0.930) and the changes of bodyweight pre and post treatmen also not significantly different, whereas p > 0.05. The study concluded that no changes in the body weight between groups and pasca induced by MSG. In the future studies, we consider to examining the effects MSG with longer of duration and more variations doses in MSG.
Highlights
Monosodium -L-glutamate is a sodium salt from glutamic acid which is widely used as flavoring ingredients .The opinions related to the adverse effects of consuming monosodium glutamate (MSG) had we found from few of studies Much of the adverse effects on human organs becaused of MSG
It has been known to have bad side effects such as damage to the liver, kidneys, brain, reproductive organs and effect to the body weight. The researcher reported their results, some argue that MSG can increase body weight (Kim et al, 2005), some argue can lose weight (Merrett, 2008), there are even studies that do not find the effect of giving MSG for weight (Tordoff, Aleman and Murphy, 2012)
This study proved that there were no differences in body weight changes before and after treatment, from the mean pre and post test it seemed to increase, but it was not statistically significantly different (p> 0.05)
Summary
Monosodium -L-glutamate is a sodium salt from glutamic acid which is widely used as flavoring ingredients (as flavoring food) .The opinions related to the adverse effects of consuming monosodium glutamate (MSG) had we found from few of studies Much of the adverse effects on human organs becaused of MSG. It has been known to have bad side effects such as damage to the liver, kidneys, brain, reproductive organs and effect to the body weight. The researcher reported their results, some argue that MSG can increase body weight (Kim et al, 2005), some argue can lose weight (Merrett, 2008), there are even studies that do not find the effect of giving MSG for weight (Tordoff, Aleman and Murphy, 2012). Glutamate will open Ca2 + channels in neurons which are located in the sense of taste which allows Ca2 + to move into the cell and fill the receptor depolarization and potential actions that lead to the brain as a delicious taste (Iswara & Yonata, 2016)
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