Abstract
Thiouracil was given to sexually immature pullets at a level of 0.05% of the diet for 14 days before and also during treatment with 0.5 mg estradiol benzoate (ODB) or 1.0 mg ODB daily for 14 days. The thiouracil treatment did not modify the estrogen-induced hypercalcemia after 7 days, but after 14 days it enhanced significantly the blood calcium response to 1.0 mg ODB per day. The positive effects of thiouracil and of estrogen on liver weight per kg live weight were significant and additive. The comparatively low level of thiouracil used did not increase liver fat per kg live weight significantly, but it increased significantly the positive effect of estrogen on liver fat. The thiouracil treatment had no significant effect on liver deoxyribonucleic acid phosphorus (DNAP) but it increased liver pentose nucleic acid phosphorus (RNAP) per kg live weight significantly both in absence and presence of estrogen. The thiouracil treatment had no effect on the responses of the oviduct to estrogen.In a second experiment the effects of (a) 1.0% thiouracil for 10 days before and also during a 14-day estrogen treatment of 1.0 mg ODB per day and of (b) 1.0% thiouracil given concurrently with 1.0 mg ODB per day were studied. Neither thiouracil treatment affected the response of the oviduct to estrogen. The other results confirmed previous observations.In a third experiment, 1.5 mg ODB was given every other day for 14 days. When thiouracil at a level of 1% was given concurrently with the estrogen, it enhanced significantly the response of the oviduct. When 1% thiouracil was given also for 10 days before the estrogen, then it did not enhance the response of the oviduct. This experiment suggests that the conditions under which thiouracil will enhance estrogen-induced hypertrophy of the oviduct are narrowly defined. Other results were in general agreement with previous observations.
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