Abstract

Sexually immature pullets were given a combined estrogen–androgen treatment, consisting of estradiol benzoate (ODB) plus testosterone propionate (TST). The influences of thiouracil and of thyroxine on various responses to this treatment were studied in two experiments. Thiouracil depressed slightly the hypertrophy of the oviduct evoked by ODB + TST; thyroxine enhanced the hypertrophy in one experiment, but depressed it in the other. Thiouracil enhanced, and thyroxine depressed the hypertrophy of the liver evoked by ODB + TST. Thiouracil also enhanced the increase of liver crude protein per kgm. live weight evoked by ODB + TST. The slight increase of liver deoxyribonucleic acid phosphorus (DNAP) per kgm. live weight evoked by ODB + TST was also enhanced by thiouracil and depressed by thyroxine. The great increase of liver pentose nucleic acid phosphorus (RNAP) per kgm. live weight evoked by ODB + TST was enhanced by thiouracil, but was depressed by thyroxine. The great increase in the ratio RNAP: DNAP in liver evoked by ODB + TST was not modified by thiouracil, but it was depressed by thyroxine. In one experiment, ODB + TST increased kidney weight per kgm. live weight; and this effect was enhanced by thiouracil and by thyroxine. In the other experiment, ODB + TST did not affect kidney weight, but the kidney weight per kgm. live weight was greater in the groups receiving either thiouracil or thyroxine than in the control group. ODB + TST did not affect kidney DNAP or RNAP per kgm. live weight, and a slight increase in kidney RNAP: DNAP observed in both experiments fell short of significance at P = 0.05. Both kidney RNAP and DNAP were significantly greater in the groups receiving thiouracil or thyroxine than in the control groups. ODB +f TST evoked a slight increase in the ratio RNAP: DNAP in kidney, and this effect was greatly enhanced by either thiouracil or thyroxine. In confirmation of previous work, the hypercalcemia evoked by ODB + TST was depressed by either thiouracil or by thyroxine.

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