Abstract
Introduction: Obesity and overweight are major worldwide public health problems associated with several etiological factors. The rs7566605 polymorphism in the INSIG-2 gene is reported to be associated with the development of obesity. This polymorphism occurs when there is a change in the nitrogenous base guanine (G) for cytosine (C) resulting in two possible mutant genotypes: CC and CG. The wild genotype is represented by GG. Many authors reported the association between this polymorphism with anthropometrical changes, but there is no consensus regarding this issue. Objective: to evaluate the frequency of rs7566605 polymorphism and its association with obesity markers in populations from different geographical areas. Method: systematic review using PubMed and following the PRISMA Guidelines. Results: there was a great variability in terms of sample size, areas, bias and phenotypic characteristics. Although 38 biological traits were evaluated, the mutation was associated with only three of them (BMI, Waist-Hip Ratio, HbA1c). The highest CC frequency was found among obese Malays (21%), and the lowest among overweight Quilombo people (3%). The highest CG frequency was found in non-obese Malays (51%), while the lowest was reported among overweight Quilombo people (22%). Also, Quilombo people reported the highest frequency of the GG phenotype (75%), while the lowest frequency was found in non-obese Malays (32%). Conclusion: The polymorphism was associated with only three obesity markers. There were specific patterns of genotypic frequency among populations belonging to similar geographical areas and/or ancestry. More research into the genetic factors related to obesity markers is needed.
Highlights
Obesity and overweight are major worldwide public health problems associated with several etiological factors
Many genes are reported to be related to the development of obesity in human populations.[10,11,12,13,14] Among those, the rs7566605 polymorphism in the insulin-induced gene 2 (INSIG-2) is described as a potential etiological factor.[11]. This polymorphism occurs when there is a change in the nitrogenous base guanine (G) for cytosine (C), which is located 10 Kb upstream of INSIG-2, resulting in two possible genotypes: CC mutant homozygous and CG heterozygous
The wild genotype is represented by GG.[15]. At high sterol concentrations the insig-2 protein inhibits the production of triglycerides, phospholipid, cholesterol and unsaturated fatty acid.[16,17] It is speculated that the rs7566605 can impact this process, but it is still unclear.[11]
Summary
Obesity and overweight are major worldwide public health problems associated with several etiological factors. The rs7566605 polymorphism in the INSIG-2 gene is reported to be associated with the development of obesity This polymorphism occurs when there is a change in the nitrogenous base guanine (G) for cytosine (C) resulting in two possible mutant genotypes: CC and CG. Many genes are reported to be related to the development of obesity in human populations.[10,11,12,13,14] Among those, the rs7566605 polymorphism in the insulin-induced gene 2 (INSIG-2) is described as a potential etiological factor.[11] This polymorphism occurs when there is a change in the nitrogenous base guanine (G) for cytosine (C), which is located 10 Kb upstream of INSIG-2, resulting in two possible genotypes: CC mutant homozygous and CG heterozygous. The aim of this study is to systematically review the literature on the distribution of rs7566605 polymorphism in different populations from several geographic areas and its relationship with obesity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
