Abstract

NORMAL levels of muscle glycogen can not be maintained in the hypophysectomized animal during a fast. The administration of pituitary growth hormone lessens the glycogen depletion, and this hormonal activity is spoken of as the glycostatic effect (1,2). Illingworth and Russell (3) investigated the glycogen response to purified growth hormone in animals with pituitaries intact. They found that in the normal animal glycogen levels were elevated significantly six hours after injection, whereas the hormone was relatively ineffective in acutely treated adrenalectomized rats. Recently, however, even in the normal animal muscle glycogen has been reported to be unaffected by growth hormone in short term experiments (4, 5). The object of the present experiments was to investigate the effects of purified growth hormone on muscle glycogen as affected by the pituitary and adrenal glands, as well as by the duration of hormone treatment.

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