The influence of the adrenal cortex on aerobic glycolysis by normal and malignant rat lymphoid tissue.

Abstract

THE regulatory influence of the adrenal cortical secretions on the structure and function of normal lymphoid tissue has been demonstrated by White and Dougherty (cf., White, 1947–48). In addition, a number of studies have indicated that the growth of lymphoid tumors may also be under the control of the adrenal cortex (Heilman and Kendall, 1944; Murphy and Sturm, 1944; Sturm and Murphy, 1944; Law and Speirs, 1947; Diller, Beck, and Blauch, 1948; Pearson, Eliel, and Rawson, 1950; Ingle and Nezamis, 1951; Emerson, 1951). These observations suggested that the metabolic behavior of normal and malignant lymphoid tissue might be influenced by variations in pituitary-adrenal cortical activity. Accordingly, investigations were undertaken of the influence of the adrenal cortex on the respiratory and aerobic glycolytic activity of normal and malignant rat lymphoid tissue, in vitro. These metabolic processes in normal lymphoid tissue were unaffected by the adrenal cortical secretions. However