Abstract
AbstractThe influence of acetone and other ketonic solvents on the bacteriostatic and bactericidal action of certain organic acids, using B. aerogenes, has been studied. The order of the bacteriostatic powers of the dibasic acids in nutrient broth was: maleic = malonic > malic > succinic; in the presence of acetone (7%) their action was greatly increased and became equal at an inhibitory dilution of 1 in 2500. Somewhat stronger solutions of the acids were required for disinfection in nutrient broth than for inhibition, and disinfection occurred at a lower pH. The germicidal power of the acids (15‐min. test at 20° in absence of organic matter) was considerably increased by acetone (20%) or by ethyl methyl ketone (7%), but triacetone‐dialcohol and ethylene glycol (30%) had less action.The dissociation of the acids at bacteriostatic and germicidal dilutions in aq. acetone (5–20%) was not affected by the acetone present, but adsorption of the acids by activated carbon was diminished.
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