Abstract
Abstract Biphasic calcium phosphate (BCP) granules were prepared using calcium hydroxide (Ca(OH)2) and orthophosphoric acid (H3PO4) as chemical precursors at Ca/P ratio 1.60 via wet chemical technique. Apart from that, silica (SiO2) was also added in the calcium phosphate material as it enhance surface chemical structure, mechanical structure and bioactivity. In this study, 3 wt% silica was added during synthesis to form slurry, before proceeding with spray drying. Granules obtained after the spray drying were calcined at different temperatures (900 – 1300 oC) to study on modulation of HA and TCP phase in BCP. Studies were also conducted on samples’ morphology resulted from spray drying and calcination process. Bioactivity study was also conducted in simulated body fluid (SBF) as a preliminary observation of sample behaviour in-vivo. Addition of silica was found to favour TCP formation and also resulted in faster dissolution process in-vitro.
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