Abstract
In this work there was investigated the influence of selenium and deodinases blockers on juvenile rats body weight during three months. The experiment was carried out on 64 rats divided into eight groups with eight individual animals per group. Following groups were formed: 1. Se+PTU-IA- (control group), 2. Se+PTU+IA+, 3. Se+PTU+IA-, 4. Se+PTU- IA+, 5. Se-PTU-IA-, 6. Se-PTU+IA+, 7. Se-PTU+IA- and 8. Se-PTU-IA+. The groups labeled (Se+) were selenium adequate and they were fed with food that contained 0.334 mg Se/kg. The groups labeled (Se-) were selenium deficient and obtained food with 0.031 mg Se/kg. As deiodinases blockers there were used propylthiouracil (PTU+) in a dose of 150 mg/L of drinking water and iopanoic acid (IA+) in a dose of 6 mg/100 g TM intraperitoneally. Body weight of experimental rats was measured every seven days. After three weeks of treatment there were taken blood samples of animals from all experimental groups and following parameters were determined: selenium concentration in blood, thyroxine (T4), triiodothyronine (T3) and thyroidstimulating hormone (TSH) in blood plasma. Analysis of the samples showed that the animals from the groups treated with PTU had lower body weight in regard to the control group, as well as lower concentration of T3 and T4 in plasma. Selenium deficient rats had lower average body weight compared to the selenium adequate ones after three weeks, but there were no differences in thyroid hormones concentration. The lowest average body weight was noticed in selenium deficient rats groups treated with PTU.
Highlights
Vet. glasnik 68 (1-2) 3 - 9 (2014) Milanović Svetlana i sar.: Uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova traciji tireoidnih hormona
Za razliku od odraslih organizama, kod kojih je smanjen nivo tireoidnih hormona vezan za povećanje telesne mase, kod mladih jedinki hipotireoidizam ima za posledicu zaostajanje u rastu gotovo kod svih kičmenjaka
Smanjena koncentracija T3 i T4 dovodi do smanjenja transkripcije iRNK za STH, a posledično i smanjene koncentracije STH u serumu (Samuels i sar., 1989)
Summary
Vet. glasnik 68 (1-2) 3 - 9 (2014) Milanović Svetlana i sar.: Uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova traciji tireoidnih hormona. Jodotironin dejodinaze (ID) su takođe selenoenzimi, odgovorni za aktivaciju i deaktivaciju tireoidnih hormona (Berry i sar., 1991). Za razliku od odraslih organizama, kod kojih je smanjen nivo tireoidnih hormona vezan za povećanje telesne mase, kod mladih jedinki hipotireoidizam ima za posledicu zaostajanje u rastu gotovo kod svih kičmenjaka. Vet. glasnik 68 (1-2) 3 - 9 (2014) Milanović Svetlana i sar.: Uticaj selena i blokatora dejodinaza na telesnu masu juvenilnih pacova
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