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Abstract
The sympathetic denervation of the kidney resulted in a significantly diminished intraglomerular fibrin deposition during the generalized Shwartzman reaction in unanesthetized rabbit when 50 mcg/kg of endotoxin was given as the provocative dose by 4-hours' infusion or by i.v. injection. This effect of renal denervation was abolished when the provocative endotoxin dose was increased to 100 mcg/kg. It is supposed that the decrease of the intraglomerular fibrin deposition in the denervated kidney following infusion or injection of 50 mcg/kg of endotoxin is a result of the suppression of vasomotor action of endotoxin mediated via sympathetic neurons.
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