Abstract
The influence of alpha- or beta-adrenergic agonists on the endotoxin-induced intraglomerular fibrin deposition (i.f.d.) was studied in rabbits with one denervated kidney. The norepinephrine infused together with the provocative endotoxin dose did not influence i.f.d. within the denervated kidney or in the intact one. The isoproterenol administered also in a common infusion with provocative endotoxin dose had no effect on i.f.d. in the intact kidney but significantly augmented this deposition within the denervated kidney. The results of the fibrinolytic activity of kidney cortex cannot explain the effects of adrenergic agonists on endotoxin-induced i.f.d. It is supposed that the enhancing effect of isoproterenol on i.f.d. within the denervated kidney can be ascribed to the vasodilating effect of this drug, promoted in the denervated kidney by the absence of endogenous norepinephrine at the nerve endings.
Published Version
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