The influence of non-alcoholic fatty liver disease on the state of the macrophagal phagocytosis system in patients with community-acquired pneumonia.

Abstract

More and more attention of researchers is at­tracted by the so-called "syndrome of mutual burdening" in combined (comorbid) pathology. The aim of the study was to analyze the effect of nonalcoholic fatty liver disease on the functional state of the macrophagal phagocytic system (MPS) in patients with community-acquired pneumonia (CAP). 85 patients with CAP of III-IV clinical group aged 18-55 years were examined. All patients were divided into two representative groups: group I (44 patients) who had CAP comorbid with hepatic steatosis (HS), group ІІ (41 patients) without chronic liver pathology. For evaluation of the functional activity of MPS, phagocytic activity of peripheral blood monocytes with analysis of phagocytic index (FI), phagocytic number (FN), index of attraction (IA) and index of digestion (ID) was studied. The results of the study revealed that in the acute period of CAP, more expressed decrease in the capacity of monocytes/macrophages to phagocytosis, the incompleteness of the phagocytic reaction, and in general, the decline in the functional activity of MPS was observed in patients with CAP comorbid with HS. After the completion of the standard treatment of patients with CAP combined with HS, moderate disturbances in the functional activity of MPS persisted. On the assumption of findings, it can be advisable to consider a further study of the effectiveness of immunotropic medicines usage, with the purpose of correcting MPS disturbances in the complex treatment and medical rehabilitation of patients with CAP comorbid with HS.