Abstract
The level of primary and secondary lipid per oxidation products were investigated: diene conjugates and malondialdehyde in conditions of nitrate loading. It was established that at bulls feeding with sodium nitrite at a dose of 0.2 hNO3ˉ/kg of body weight, the level of diene conjugates and malondialdehyde in their was increased during the entire the experiment. On the 30thday of the experiment the level of diene conjugates in blood of bull, which were conducted with nitrate load was 7.44 ± 0.15 mmol/l, and the level of malondialdehyde – 0.305 ± 0.014 mmol/l.Under conditions of nitrate load , young cattle was used a new integrated drug «Metisevit», which consists of sodium selenite, vitamin E and metifen. It was found the stimulating effect of metifen and metisevit on antioxidant system of the body of young cattle. Depressing effect of metifen and metisevit on the processes and lipid per oxidation in the blood of bulls under conditions of chronic nitrate–nitrite toxicity. Metifen and metisevit interact with radicals of fatty acids and delay the development of a chain reaction of oxidative stress, reduce the oxidation of phospholipids and form a biologically inactive compound with products of per oxidation of fats. Obtained results of the research indicate antioxidant drugs «Metisevit» and «Metifen» in the application of their young cattle.The mentioned changes are occurring through the comprehensive action of the drug components «Medisvit», that leads to the normalization of metabolic processes and free radical in the body of bulls. Obtained results of the research indicate the antioxidant action of the drugs «Metisevit» and «Metifen» in the application of their young cattle and the reasonableness of their administration to improve the antioxidant status of the organism according to nitrate loading.
Highlights
The analysis of available domestic and foreign literature gives reason to assert that due to the ever–increasing ejection nitrogen compounds in the air and water basins, toxicity issues of nitrates and nitrites in our time are of special attention (Guberuk et al, 2010, 2012, 2015)
A large number of messages are accumulated about the important role of lipid per oxidation (LPO) in the development of many toxicosis (Baglaj et al, 2011; Gutyj, 2013; Guberuk et al, 2015)
Having established that during the nitrate–nitrite toxicity are coming disorders of lipid per oxidation, we concluded that under the influence of nitrates and nitrites for suppression of excessive free radical reactions in animals body, preparations should be used with a strong antioxidant effect, which can inhibit lipid per oxidation
Summary
The analysis of available domestic and foreign literature gives reason to assert that due to the ever–increasing ejection nitrogen compounds in the air and water basins, toxicity issues of nitrates and nitrites in our time are of special attention (Guberuk et al, 2010, 2012, 2015). A large number of messages are accumulated about the important role of lipid per oxidation (LPO) in the development of many toxicosis (Baglaj et al, 2011; Gutyj, 2013; Guberuk et al, 2015). From the large number of antioxidants at nitrate–nitrite toxics of bulls, we have studied the prophylactic action of metisevit and metifen. These antioxidants are blocking free radicals – products of met hemoglobin creation and prevent the development of oxidative stress in animals (Guberuk et al, 2015; Martyshuk et al, 2016)
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