Biochemical changes in the blood of domestic dogs with cardiomyopathy in the setting of obesity

Abstract

In clinical settings, cardiac biomarkers with high sensitivity and specificity can be used to predict or diagnose heart disease. In humane clinical practice, troponins I and T have been used as predictors of heart disease, and the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) is also considered the most reliable predictor of heart disease. Veterinary cardiac biomarkers are not yet widely used by practitioners in the diagnosis of heart disease, but this does not negate the high informative value of specific cardiac parameters such as canine N-terminal pro-B-type natriuretic peptide (cNT-proBNP) and canine cardiac troponin I (ccTnI). Given the above, there is a need to conduct biochemical blood tests for cardiac pathology in dogs. The aim of the study was to determine specific parameters (cNT-proBNP and ccTnI) and blood lipidogram of domestic dogs with cardiomyopathy in the setting of obesity. The analysis of blood tests showed an increase in the content of ccTnI by more than 20 times (Р < 0.001) and cNT-pro BNP by 17.6 times (Р < 0.001) in domestic dogs with cardiomyopathy in the setting of obesity. According to the results of lipidogram determination, the dogs of the experimental group showed an increase in total cholesterol by 66.9 %, low-density lipoprotein (LDL) by 8.4 times, and very low-density lipoprotein (VLDL) by 4.2 times. The studies showed significant changes in blood biochemical parameters in cardiomyopathy in domestic dogs with obesity, which confirms the diagnostic value of these biomarkers. The research results deserve the attention of the veterinary community of practitioners and can be used in the diagnosis and subsequent prognosis of heart disease in the future.