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Abstract
Abstract. The paper studies the effect of aqueous solutions of melamine salt ofphosphonic acid (Melafen), used in crop production, on structural and thermodynamicproperties of phospholipid membranes. The multilamellar liposomes formed fromindividual synthetic dimyristoylphosphatidylcholine (DMPC), or natural phospholipidmixture (egg lecithin) was studied by differential scanning microcalorimetry (DSC) andsmall-angle X-ray scattering (SAXS).The method of DSC was used to appraise the influence of Melafen aqueous solutions(10 –17 M to 10 –3 M) on thermodynamic parameters of lipid melting (temperature, enthalpy andcooperation of phase transition) in suspension of liposomes formed from DMPC. On the basisof DSC data it was concluded that the microdomain structural organization of DMPCmembranes was altered by Melafen aqueous solutions as polymodal type.We did not reveal by the SAXS method any noticeable integral structural changes inmembranes of egg lecithin in multilamellar liposomes as well as in their stacking parameters(period and degree of order) in Melafen aqueous solutions (10
Highlights
In most cases the primary targets for biologically active substance (BAS) are the cell membranes
The method of differential scanning microcalorimetry (DSC) was used to appraise the influence of Melafen aqueous solutions (10–17 M to 10–3 M) on thermodynamic parameters of lipid melting in suspension of liposomes formed from DMPC
In the first part of this work we investigated the action of Melafen aqueous solution under the wide range of concentrations (10-17 M – 10-3 M)
Summary
In most cases the primary targets for biologically active substance (BAS) are the cell membranes. The method of DSC was used to appraise the influence of Melafen aqueous solutions (10–17 M to 10–3 M) on thermodynamic parameters of lipid melting (temperature, enthalpy and cooperation of phase transition) in suspension of liposomes formed from DMPC. We did not reveal by the SAXS method any noticeable integral structural changes in membranes of egg lecithin in multilamellar liposomes as well as in their stacking parameters (period and degree of order) in Melafen aqueous solutions (10–21 M to 10–6 M).
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