Abstract
The effect of nicotinic acid on the metabolism of lipids in rats exposed to carbon disulphide has been investigated. Rats were exposed to carbon disulphide in concentration 0.55 mg/l over 8 months. Parallely with exposure nicotinic acid was administered in drinking water in two doses: 8 and 40 mg/kg per day. The concentration of lipids in blood plasma and the rate of synthesis of cholesterol in liver were assessed in the course of exposure. An elevated level of lipids in plasma and accelerated synthesis of cholesterol in liver brought about by carbon disulphide exposure have been found. The above changes could be prevented by feeding of nicotinic acid in dose of 40 mg/kg per day, but not by the lower dose of 8 mg/kg. The mechanism of these processes is discussed.
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