Childhood exposure to polycyclic aromatic hydrocarbons is associated with emotional and behavioral problems in adolescence: a longitudinal study in China.

Abstract

The aim of this study was to investigate the relationship between childhood polycyclic aromatic hydrocarbon (PAH) exposure and emotional and behavioral problems in adolescence. Participants included 998 school-age children aged 7-12 years (514 girls and 484 boys). Metabolite concentrations of four PAHs (1-hydroxypyrene [1-OHPyr], 2-hydroxynaphthalene [2-OHNap], 2-hydroxyfluorine [2-OHFlu], and 9-hydroxyphenanthrene [9-OHPhe]) were measured in urine samples at baseline (Dec 2014-Dec 2015). During adolescence, we measured emotional and behavioral problems in study participants. We used logistic regression models to assess the effects of different levels of PAH metabolite concentrations on emotional and behavioral problems for boys and girls, separately. Boys exposed to 1-OHPyr and 2-OHFlu had a significantly higher risk of externalizing problems (OR: 2.62, 95% CI: 1.09 ~ 6.29; OR: 2.92, 95% CI: 1.15 ~ 7.42). 2-OHNap exposure faced a higher risk of internalizing problems (OR: 3.85, 95% CI: 1.28 ~ 11.58; OR: 3.63, 95% CI: 1.13 ~ 11.63) and externalizing problems (OR: 4.27, 95% CI: 1.44 ~ 12.70; OR: 4.68, 95% CI: 1.49 ~ 14.73). Moreover, boys exposed to 9-OHPhe exhibited a significant risk of anxiety (OR: 2.84, 95% CI: 1.01 ~ 7.97; OR: 3.00, 95% CI: 1.04 ~ 8.68). Similarly, girls exposed to 9-OHPhe had a significant risk of anxiety (OR: 2.41, 95% CI: 1.25 ~ 4.64). Childhood PAH exposures are associated with emotional and behavioral problems in adolescence, and boys seem more susceptible than girls.