Abstract
An investigation was made of the effect produced by gamma-aminobutyric acid (GABA) on the contraction of the normal and denervated adductor muscle of the claw ofAstacus Astacus and ofAstacus Leptodactylus. GABA was shown to exert an inhibitory effect on normal muscular contraction, a result which agreed with published reports. In simulating the action of the inhibitory nerve, GABA evidently acts on the nerve endings to promote the appearance of the mediator. There was no GABA effect on the muscular contraction after section of the inhibitory nerve alone, or after total denervation. The muscle was sensitive to GABA after division of the motor nerves and retention of the inhibitory innervation. Low GABA concentrations selectively blocked the slow component of this reaction, in both normal and in denervated muscle.
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