Abstract
The aging brain and changes in GABA concentrations
Highlights
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain
Since regional GABA concentration has been found to be correlated with various behavioral measures (Puts & Edden, 2012; Stagg, 2014), insight into the effect of healthy aging on brain chemistry may increase our understanding of the underlying neural mechanisms that contribute to cognitive and motor deficits in older adults
Statistical analysis indicated that there was no effect of age on GABA+ concentrations (F1,106.4 = 0.317, p = .574), but there was an interaction between age and voxel (F8, 404.8 = 2.009, p = .0442)
Summary
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain. Previous literature revealed a decline in GABA concentration in frontal and parietal regions as a result of age (Gao et al, 2013; Porges et al, 2017). It is not clear whether this age-related decline in GABA concentration is specific to these regions or a widespread effect.
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