Abstract
The effects of a light or heavy breakfast on the absorption of acyclovir (400 mg), containing technetium-99m labelled resin and administered as a suspension to 6 healthy volunteers, has been followed using gamma scintigraphy and measurement of plasma concentration. The heavier meal slowed the rate of gastric emptying, prolonged small intestinal transit time and significantly decreased absorption of the drug. No correlation was found between the small intestinal transit time and the area under the plasma concentration time curve.
Published Version
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